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The Latest 49ers Odds For NFL Season 2025
Pick Your
Sportsbook
DraftKings
FanDuel
BetMGM
BetRivers
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ESPN Bet
Hard Rock
San Francisco 49ers
0-0 (0-0 in the NFC West)
Loading Possible Bets...
49ers Week 1 Matchup
Sunday at 4:05 pm EST
San Francisco 49ers
@
Seattle Seahawks
Moneyline
DraftKings
–
Spread
DraftKings
PICK
Over Under
DraftKings
– Pts
Explore 49ers at Seahawks Matchup
Loading Schedule...
Projected Record: 11-6 (3-3 NFC West)
Win Totals
DraftKings
10.5
Wins
PROBABILITY
with vig removed
Over 10.5 Wins
(110)
45.7%
Under 10.5 Wins
(-130)
54.3%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Super Bowl
DraftKings
+2000
LINE MOVEMENT
NFC Champ
DraftKings
+1000
LINE MOVEMENT
NFC West
DraftKings
+150
LINE MOVEMENT
49ers Injury Report
Loading 49ers Injuries...
49ers News
RB
Isaac Guerendo: On field for OTAs
Jun 6th
Guerendo (knee/ankle) was an active participant at voluntary OTAs, per
the 49ers' official site
.
WR
Malik Knowles: Lands in Bay Area
Jun 3rd
Knowles
signed a one-year contract
with the 49ers on Tuesday.
WR
Trent Taylor: Lands on IR
Jun 3rd
The 49ers placed Taylor (undisclosed) on
injured reserve
Tuesday.
OT
Trent Williams: Active for OTAs
Jun 3rd
Williams (ankle) has been an active participant at the 49ers' OTAs,
Vic Tafur of The Athletic
reports.
LB
Bryce Huff: Deal to SF finalized
Jun 2nd
Huff was traded from the Eagles to the 49ers on Monday in exchange for a conditional fifth-round pick in 2026,
Adam Schefter of ESPN
reports.
Read More 49ers News
CB
Tre Brown: Participating in OTAs
May 30th
Brown (knee) participated in Thursday's organized team activities,
Matt Barrows of The Athletic
reports.
CB
Renardo Green: Past groin issue
May 30th
Green (groin) participated in Thursday's organized team activities,
Grant Cohn of Spots Illustrated
reports.
OG
Spencer Burford: Returns to gridiron
May 30th
Burford (calf) participated in Thursday's organized team activities,
Matt Barrows of The Athletic
reports.
S
Ji'Ayir Brown: Dealing with ankle issue
May 29th
Brown will be out until training camp after undergoing a procedure on his ankle,
Cam Inman of The San Jose Mercury News
reports.
WR
Ricky Pearsall: Tweaks hamstring
May 29th
Pearsall is dealing with a hamstring injury, according to head coach Kyle Shanahan,
Nick Wagoner of ESPN.com
reports.
49ers Depth Chart
Quarterback
QB
Brock Purdy
Mac Jones
Kurtis Rourke
Ques
Tanner Mordecai
Running Back
RB
Christian McCaffrey
Isaac Guerendo
Jordan James
Patrick Taylor
Israel Abanikanda
Corey Kiner
Wide Receiver
WR
Brandon Aiyuk
Ques
Jauan Jennings
Ricky Pearsall
Ques
Demarcus Robinson
Jacob Cowing
Jordan Watkins
Russell Gage
Terique Owens
Junior Bergen
Isaiah Hodgins
Isaiah Neyor
Malik Knowles
Trent Taylor
IR
Tight End
TE
George Kittle
Luke Farrell
Ross Dwelley
Brayden Willis
Jake Tonges
Mason Pline
Fullback
FB
Kyle Juszczyk