49ers vs Seahawks Week 1 Odds
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Seattle Seahawks vs San Francisco 49ers in week.

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49ers
Seahawks
Sunday September 7, 2025 at 4:05 PM ET
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Moneyline
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SF Win or Lose By < 0 Pts()
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SEA Win or Lose By < 0 Pts()
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Player Props
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
Inactives
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SEA
Seahawks Lineup
Inactives
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SF
49ers News
#2 RB
Isaac Guerendo: On field for OTAs
Jun 6th
Guerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers' official site.
#12 WR
Malik Knowles: Lands in Bay Area
Jun 3rd
Knowles signed a one-year contract with the 49ers on Tuesday.
#13 WR
Trent Taylor: Lands on IR
Jun 3rd
The 49ers placed Taylor (undisclosed) on injured reserve Tuesday.
#1 LT
Trent Williams: Active for OTAs
Jun 3rd
Williams (ankle) has been an active participant at the 49ers' OTAs, Vic Tafur of The Athletic reports.
#1 WLB
Bryce Huff: Deal to SF finalized
Jun 2nd
Huff was traded from the Eagles to the 49ers on Monday in exchange for a conditional fifth-round pick in 2026, Adam Schefter of ESPN reports.
#2 LCB
Tre Brown: Participating in OTAs
May 30th
Brown (knee) participated in Thursday's organized team activities, Matt Barrows of The Athletic reports.
#1 RCB
Renardo Green: Past groin issue
May 30th
Green (groin) participated in Thursday's organized team activities, Grant Cohn of Spots Illustrated reports.
#2 LG
Spencer Burford: Returns to gridiron
May 30th
Burford (calf) participated in Thursday's organized team activities, Matt Barrows of The Athletic reports.
#1 SS
Ji'Ayir Brown: Dealing with ankle issue
May 29th
Brown will be out until training camp after undergoing a procedure on his ankle, Cam Inman of The San Jose Mercury News reports.
#3 WR
Ricky Pearsall: Tweaks hamstring
May 29th
Pearsall is dealing with a hamstring injury, according to head coach Kyle Shanahan, Nick Wagoner of ESPN.com reports.
#1 P
Thomas Morstead: Picked up by San Francisco
May 28th
Morstead signed with the 49ers on Wednesday.
SEA
Seahawks News
#1 RT
Abraham Lucas: Able to take part in OTAs
Jun 6th
Lucas (abdomen) has been participating in the Seahawks' offseason training activities, Cameron Van Til of Seattle Sports reports.
#2 RG
Anthony Bradford: Competing for starting role in OTAs
Jun 6th
Bradford (ankle) is healthy for the Seahawks' offseason training activities and has seen some work with the first-team offense, Justin Melo of Seahawks Wire reports.
#1 WLB
DeMarcus Lawrence: Healthy to begin Seahawks tenure
Jun 6th
Lawrence (foot) has been participating in OTAs, Michael-Shawn Dugar of The Athletic reports.
#1 RILB
Ernest Jones: Progressing well in recovery
Jun 5th
Jones' recovery from offseason knee surgery is "going as planned," Bob Condotta of The Seattle Times reports.
#2 RDE
Rylie Mills: Back from ACL injury
Jun 5th
Mills (knee) was getting "half speed work" in during OTAs on Thursday, Corbin Smith of emeraldcityspectrum.com reports.
#7 TE
Mitch Van Vooren: Signs with Seattle
Jun 4th
The Seahawks signed Van Vooren on Wednesday.
#1 RCB
Riq Woolen: Active during OTAs
Jun 4th
Woolen (ribs) participated during OTAs on Monday, Edwin Hooper of the Seahawks' official site reports.
#1 RB
Kenneth Walker: On field for OTAs
Jun 4th
Walker (ankle) is participating in Seattle's voluntary OTAs, per the team's official site.